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An in-depth article by Nature on what we know about the SARS-CoV-2 virus and what makes the Delta variant so much more infectious.

"What has emerged from 19 months of work, backed by decades of coronavirus research, is a blow-by-blow account of how SARS-CoV-2 invades human cells"

nature.com/articles/d41586-021

· · Web · 2 · 12 · 8

@sohkamyung Wow. I didn't realise they had an understanding of why cq didn't actually work:

The virus’s speedy entry using TMPRSS2 explains why the malaria drug chloroquine didn’t work in clinical trials as a COVID-19 treatment, despite early promising studies in the lab10. Those turned out to have used cells that rely exclusively on cathepsins for endosomal entry. “When the virus transmits and replicates in the human airway, it doesn’t use endosomes, so chloroquine, which is an endosomal disrupting drug, is not effective in real life,” says Barclay.

@loke Indeed. Makes you wonder why people still keep pushing it as a treatment for COVID-19.

@sohkamyung the same reason people think vaccines don't help. Misinformation, conspiracy theories, distrust in science, etc.

@sohkamyung By the way, have you made the mistake of reading youtube comments in the videos of the ministers doing COVIS reports? That's a crazy amount of antivax propaganda.

@loke No. I usually don't read the comments on articles and videos in general. 🙂

@sohkamyung Good. Please don't. You'll just get very upset about it.

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